Prize Observer

Base editing and prime editing · explained

research · explained

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Base editing changes particular DNA base pairs using targeted molecular machinery; prime editing uses a different design to write sequence changes. Neither should be described as unrestricted or error-free editing. Delivery, unintended changes and the biological context still matter.

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work and contributions

David R. Liu

A chemical biologist whose laboratory developed base editing and prime editing. These approaches offer ways to alter DNA sequences without relying on conventional double-strand-break editing.

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